Television-produced collection premiered September 21, 2015, on NBC. On May 10, 2019, NBC recovered the collection for a 5th as well as last period, which is readied to contain 11 episodes as well as premiered on May 7, 2020.
- Sullivan Stapleton as Kurt Weller, an FBI unique representative at the New York area workplace. In period 1, as head of the FBI Critical Incident Response Group, he is called right into the examination of Jane when his name is discovered strangely tattooed on Jane's body. He pertains to identify Jane as his missing out on childhood years pal Taylor Shaw as well as ends up being extremely safety, because of having actually never ever recuperated from the discomfort as well as regret he experienced her loss. It is disclosed in the period 1 ending that he has actually been advertised to head of the FBI's New York branch after Mayfair's loss, with this being the objective of Stage One of the conspiracy theory behind Jane's tattoos as the tattoo examinations got rid of much less moral possible prospects. In period 3, he as well as Jane wed.
- Jaimie Alexander as Remi “Jane Doe” Briggs (birthed Alice Kruger), an unknown lady discovered nude as well as amnesiac in Times Square, that is maintained in FBI safety custodianship as an examination continues right into her identification. Despite doing not have aware memories, Jane sometimes has recalls to her previous life as well as keeps a wide array of battle as well as language abilities. It is believed she is a previous Navy SEAL, whose identification is identified because of participation in unique procedures. Based on an acquainted mark on the back of her neck as well as a DNA examination, Jane was thought to be Taylor Shaw. Shaw was Weller's next-door neighbor as well as childhood years pal, that disappeared 25 years earlier as well as was assumed departed, yet the genuine Taylor Shaw was verified to be dead when Weller's daddy admitted to her murder on his deathbed. Weller ultimately discovered Taylor's stays in an old campground they remained in as youngsters; the DNA examination outcomes were changed by the conspiracy theory transforming the documents of the Taylor Shaw instance. It is later disclosed that Jane was birthed Alice Kruger in South Africa, after that orphaned as well as educated as a child soldier by the apartheid regime. Shepherd eventually adopted her as well as raised her as a daughter. In season 3, she marries Weller. At the end of the season, she reverts to her previous persona as Remi as a result of side effects from ZIP, the drug that originally wiped her memories. During the first half of season 4, she, as Remi, starts secretly working against her team in a bid to free Shepherd as well as rebuild Sandstorm, but is soon found out, and following a successful experimental treatment, Jane finally puts her past behind her, makes peace with Remi, regains all of her memories, and kills Shepherd.
- Rob Brown as Edgar Reade, an FBI special agent and member of Weller's team, who has doubts about Jane's inclusion on the team and expresses skepticism of Weller's willingness to follow the information from Jane's tattoos so quickly. He is in love with Weller's sister, Sarah, but broke up with her both on Weller's request and because Reade feared for Sarah's safety after one of the group behind Jane's tattoos threatened Sarah when Reade was trying to investigate Jane's background. In period 3, he becomes the head of the New York field office after Jane and Weller leave New York and was engaged to Megan Butani, an investigative journalist. They later broke up. He also has romantic feelings for Zapata, which he finally acts on late in season 4. It is short-lived, as he is killed in the drone strike at completion of the period, as revealed in the season 5 premiere.
- Audrey Esparza as Natasha “Tasha” Zapata, an FBI special agent and member of Weller's team, previously an NYPD officer at the 96th District for five years. Secretly, she has a gambling addiction, caused by guilt from the death of her partner while with the NYPD, and is in severe debt, which she hides from her co-workers. She is also shown to have feelings for Reade. In season 3, she leaves the FBI and joins the CIA. At the end of the season, she is seemingly terminated from the CIA, and goes to work for Blake Crawford as a fixer, but following Blake's death in season 4, she works for her successor, Madeline Burke. Midway through the season, it is revealed that she was working deep cover for the CIA all along under Director Jake Keaton.
- Ashley Johnson as William Patterson, an FBI special agent and head of the FBI Forensic Science Unit, responsible for studying and identifying Jane's tattoos. In season 3, she departs the FBI to work in the tech industry, but returns to help solve Jane's new tattoos. Later in the season, it is also revealed that Patterson is the daughter of Bill Nye and took her mother's last name.
- Ukweli Roach as Robert Borden (seasons 1–2; recurring season 3; guest season 4), an FBI psychiatrist who helps Jane in retrieving and understanding her past memories. He is later revealed to be Nigel Thornton, a former doctor and a mole for Sandstorm within the FBI. After being cornered by the FBI, he apparently kills himself to avoid capture. In season 3, however, it is revealed that he had faked his death, and was later found and recruited by the CIA as an asset. He is later sent to prison after Zapata reneges on his deal with the CIA as justice for betraying Patterson. In season 4, Jane visits him and he helps her to finally accept her lives and personas of Remi and Alice as part of herself.
- Marianne Jean-Baptiste as Bethany Mayfair (season 1; guest season 2), assistant director in charge of the FBI's New York Field Office. Mayfair is directly in charge of Weller and his team, for whom Mayfair acts as an ally and mentor. She was once the FBI contact for Operation: Daylight, a program to use illegally obtained information and present it as coming from faked informants; it is hinted that Jane's tattoos have some connection to Daylight. After Mayfair is framed for murder due to evidence Jane was manipulated into planting, she is fatally shot by Oscar just as she discovers Jane at a safe house used by the conspiracy.
- Archie Panjabi as Nas Kamal (season 2; guest season 3), head of Zero Division, a secret department of the NSA. She has investigated Sandstorm for years, and forms a joint NSA-FBI task force with Weller's team and Jane to try to infiltrate Sandstorm. In order to protect the team from federal investigation, she resigns, taking responsibility for all of the task force's failures. She spends time working freelance before she is able to use a tattoo case to acquire a powerful computer virus, trading it to the NSA in return for getting her job back.
- Luke Mitchell as Roman Briggs (born Ian Kruger) (seasons 2–3; recurring season 4), Jane's brother and a member of Sandstorm. Jane wiped his memory with ZIP (the same drug that wiped her memories) after he turned against Shepherd, and he remained in FBI custody for a while. After regaining his memories, including that of Jane erasing his memories, he turns against her and rejoins Shepherd during her attack on the FBI's New York Office. In season 3, he devises a complex scheme to get revenge on Jane that involves covering her with new, bio-luminescent tattoos. At the end of the season, he is fatally shot by Blake Crawford, and dies in Jane's arms. In season 4, he appears as a hallucination as a result of Jane/Remi's ZIP poisoning.
- Michelle Hurd as Ellen “Shepherd” Briggs (season 2; guest seasons 3–4), Jane's and Roman's adoptive mother and leader of the terrorist group Sandstorm. She was a major general with the Defense Threat Reduction Agency, and has been manipulating Weller's life since he was a teenager. She is captured at the end of season 2 after Jane and Weller foil her plans, and imprisoned in a CIA blacksite until Jane, reverted to her character of Remi, frees her during season 4. She is later shot and killed by Jane after the latter finally overcomes the mental effects of ZIP.
- Ennis Esmer as Rich Dotcom (real name Gord Enver) (seasons 4–5; recurring seasons 1–3), a former computer programmer turned Internet crime lord. Eccentric and manic, Rich often embroils Weller's team in elaborate, convoluted schemes to achieve his goals. In season 3, he begins working with the FBI as part of a deal for his past crimes.
- Mary Elizabeth Mastrantonio as Madeline Burke (season 5; recurring season 4), a major stockholder in the Crawfords' company HCI Global, who takes over the company after fatally poisoning Blake and the other executives as part of a mysterious long-term plan. At the end of the season, her plan, Project: Helios, takes effect, causing a major blackout on the Eastern Seaboard while framing the team for the attack and corruption, and becoming the head of an oversight committee for the FBI and later director of all federal law enforcement; all this is revealed to be part of a plan to avenge her father, who was killed in an FBI raid.
On January 23, 2015, a pilot was ordered by NBC. The pilot was written by Martin Gero, who was also set to serve as executive producer alongside Greg Berlanti. On February 12, 2015, it was reported that Mark Pellington would direct the pilot episode.
On May 1, 2015, NBC gave the production a series order. It was also reported that Berlanti Productions, Quinn's House and Warner Bros. Television would serve as additional production companies. A few days later, it was announced that the series would premiere in the fourth quarter of 2015. On July 11, 2015, the premiere date was set for September 21, 2015. A back nine order was given on October 9, 2015, bringing the very first period to a total of 22 episodes, along with an order for an additional episode, bringing the first season episode count to 23. On November 9, 2015, it was announced that the series had been renewed for a second season. The second season premiered on September 14, 2016. On May 10, 2017, the show was renewed for a third season, which premiered on October 27, 2017. On May 10, 2018, NBC renewed the series for a fourth season that premiered on October 12, 2018. On May 10, 2019, NBC renewed the series for a fifth as well as final season of 11 episodes. The season was set to air in mid-2020, yet due to the airing of a Parks as well as Recreation unique, it will instead best on May 7, 2020.